MARK-IN-1
Modify Date: 2025-08-26 18:22:28
MARK-IN-1 structure
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Common Name | MARK-IN-1 | ||
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| CAS Number | 1109283-93-3 | Molecular Weight | 471.52600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23F2N7OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MARK-IN-1MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM. |
| Name | N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide |
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| Description | MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM. |
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| Related Catalog | |
| Target |
IC50: <0.25 nM (MARK)[1] |
| In Vitro | MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1]. |
| References |
| Molecular Formula | C22H23F2N7OS |
|---|---|
| Molecular Weight | 471.52600 |
| Exact Mass | 471.16500 |
| PSA | 131.37000 |
| LogP | 4.50280 |
| InChIKey | SFILVHFYISPBOI-IEBWSBKVSA-N |
| SMILES | Cc1sc(C(=O)NC2C(N)CCCC2(F)F)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 |