Utibapril

Modify Date: 2025-09-15 20:46:17

Use of Utibapril

Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.

Name	5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid
Synonym	More Synonyms

Description	Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease
In Vivo	Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].
References	[1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. [2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4.

Density	1.24g/cm3
Boiling Point	597.5ºC at 760 mmHg
Molecular Formula	C₂₂H₃₁N₃O₅S
Molecular Weight	449.56400
Flash Point	315.2ºC
Exact Mass	449.19800
PSA	133.60000
LogP	2.63910
Vapour Pressure	3.98E-15mmHg at 25°C
Index of Refraction	1.586
InChIKey	FTYVYAGWBXTWTN-ZVZYQTTQSA-N
SMILES	CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1N=C(C(C)(C)C)SC1C(=O)O
Storage condition	2-8℃

Utibaprilo

Utibaprilo [INN-Spanish]

5-tert-butyl-3-[n-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid

Utibapril

Utibaprilum [INN-Latin]

Utibaprilum

5-tert-butyl-3-{N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylic acid

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Price: $696/1mg

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