Utatrectinib
Modify Date: 2024-03-07 09:09:57
Utatrectinib structure
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Common Name | Utatrectinib | ||
|---|---|---|---|---|
| CAS Number | 1079274-94-4 | Molecular Weight | 382.395 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 645.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C18H19FN8O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 344.4±34.3 °C | |
Use of UtatrectinibUtatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors[1]. |
| Name | AZD-7451 |
|---|---|
| Synonym | More Synonyms |
| Description | Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Utatrectinib (100 nM, 22 h) inhibits the migration of TrkC-expressing U2SO cells[2]. Utatrectinib (1-10 nM, 24 h) inhibits cell growth in KM12, H460 and H810 cells[3]. Utatrectinib (5 nM, 24 h) inhibits phosphorylation of TRKA/B and downstream signaling in KM12, H460 cells[3]. Cell Migration Assay [2] Cell Line: TrkC-expressing U2SO cells Concentration: 100 nM Incubation Time: 22 h Result: Inhibited cell migration (~2.3-fold, P<0.01). Western Blot Analysis[3] Cell Line: KM12, H460 cells Concentration: 0, 1, 5 nM Incubation Time: 24 h Result: Inhibited pTRKA Tyr490 and pAk in KM12 cells. Inhibited pTRKB Tyr706/707 and pERK in H460 cells. |
| In Vivo | Utatrectinib (50 mg/kg, p.o., daily) suppresses adenoid cystic carcinoma (ACC) tumor growth in ACCX6 xenograft nu/nu mice model[2]. Animal Model: Xenograft nu/nu mice models of human ACC: ACCX6 and ACCX9[2] Dosage: 50 mg/kg Administration: Oral administration, daily. Result: Tumor growth inhibition (TGI): 64% (in ACCX6 model) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 645.9±65.0 °C at 760 mmHg |
| Molecular Formula | C18H19FN8O |
| Molecular Weight | 382.395 |
| Flash Point | 344.4±34.3 °C |
| Exact Mass | 382.166595 |
| LogP | 1.04 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.712 |
| 3H-Imidazo[4,5-b]pyridin-5-amine, N-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-3-[5-(1-methylethoxy)-1H-pyrazol-3-yl]- |
| AZD-7451 |
| N-[(1S)-1-(5-Fluoro-2-pyrimidinyl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine |
| VNM956Y27V |