Kazusamycin B

Modify Date: 2024-01-20 11:59:37

Kazusamycin B structure	Common Name	Kazusamycin B
	CAS Number	107140-30-7	Molecular Weight	542.70
	Density	1.118g/cm3	Boiling Point	754.2ºC at 760 mmHg
	Molecular Formula	C₃₂H₄₆O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	236.5ºC

Use of Kazusamycin B

Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer[1][2].

Name	(2E,10E,12E,16Z,18E)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid

Description	Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
In Vitro	Kazusamycin B (PD 124895; 5 ng/mL; 24 h; 1210 cells) 具有时间依赖性的细胞毒性，使细胞周期停滞在 G1 期[2]。 Kazusamycin B (5-50 ng/mL; 0-6 h; 1210 cells) 适度抑制 RNA 合成，但特异性抑制 2 小时[2]。 Cell Cycle Analysis[2] Cell Line: 1210 cells Concentration: 5 ng/mL Incubation Time: 24 h Result: Arrested cell cycle at G1 phase at 4 hours.
References	[1]. Funaishi K, et, al. Kazusamycin B, a novel antitumor antibiotic. J Antibiot (Tokyo). 1987 Jun;40(6):778-85. [2]. Takamiya K, et, al. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. J Antibiot (Tokyo). 1988 Dec;41(12):1854-61.

Density	1.118g/cm3
Boiling Point	754.2ºC at 760 mmHg
Molecular Formula	C₃₂H₄₆O₇
Molecular Weight	542.70
Flash Point	236.5ºC
Exact Mass	542.32400
PSA	121.13000
LogP	5.36700
Vapour Pressure	2.96E-26mmHg at 25°C
Index of Refraction	1.554

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OA0551000

CHEMICAL NAME :: Kazusamycin B

CAS REGISTRY NUMBER :: 107140-30-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C32-H46-O7

MOLECULAR WEIGHT :: 542.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 10 ng/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 41,1854,1988

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PD 124895
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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