NS13001
Modify Date: 2025-09-11 17:08:34
NS13001 structure
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Common Name | NS13001 | ||
|---|---|---|---|---|
| CAS Number | 1063331-94-1 | Molecular Weight | 353.80900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H16ClN7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NS13001NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1]. |
| Name | (4-chloro-phenyl)-[2-(3,5-dimethyl-pyrazol-1-yl)-9-methyl-9H-purin-6-yl]-amine |
|---|---|
| Synonym | More Synonyms |
| Description | NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1]. |
|---|---|
| Target |
EC50: 1.8 μM (SK2), 0.14 μM (SK3)[1] |
| References |
| Molecular Formula | C17H16ClN7 |
|---|---|
| Molecular Weight | 353.80900 |
| Exact Mass | 353.11600 |
| PSA | 73.45000 |
| LogP | 3.63580 |
| InChIKey | DVQOPNIPUIOXHU-UHFFFAOYSA-N |
| SMILES | Cc1cc(C)n(-c2nc(Nc3ccc(Cl)cc3)c3ncn(C)c3n2)n1 |
| (4-chlorophenyl)-[2-(3,5-dimethylpyrazol-1-yl)-9-methyl-9H-purin-6-yl]amine |
| NS13001 |
| (4-chloro-phenyl)-[2-(3,5-dimethyl-pyrazol-1-yl)-9-methyl-9H-purin-6-yl]amine |
| N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine |