NC-043
Modify Date: 2023-01-11 17:14:58
NC-043 structure
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Common Name | NC-043 | ||
|---|---|---|---|---|
| CAS Number | 1053172-87-4 | Molecular Weight | 330.418 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 549.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H30O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 198.5±23.6 °C | |
Use of NC-043NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association; decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo; inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth. |
| Name | (5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione |
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| Synonym | More Synonyms |
| Description | NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association; decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo; inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth. |
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| References | References 1. Wang W, et al. Cell Res. 2011 May;21(5):730-40. 2. Yan M, et al. Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197. 3. He X, et al. Cell Discov. 2017 Jan 31;3:17003. View Related Products by Target Beta-catenin |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 549.2±50.0 °C at 760 mmHg |
| Molecular Formula | C22H30O4 |
| Molecular Weight | 330.418 |
| Flash Point | 198.5±23.6 °C |
| Exact Mass | 330.183105 |
| LogP | 1.41 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.588 |
| Storage condition | 2-8°C |
| (5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione |
| Atis-16-ene-15,20-dione, 18,20-epoxy-7-hydroxy-, (5β,7α,8α,9β,10α,12α)- |