Oenothein B
Oenothein B structure
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Common Name | Oenothein B | ||
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| CAS Number | 104987-36-2 | Molecular Weight | 1569.08000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C68H48O44 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Oenothein BOenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2]. |
| Name | oenothein B |
|---|
| Description | Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2]. |
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| Related Catalog | |
| In Vitro | Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1]. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1]. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1]. A549 cells[1]15 µM, 30 µM and 45 µM24 hoursArrested cells in the G1 phase.A549 cells[1]15 µM, 30 µM and 45 µM24 hoursBAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 15 µM, 30 µM and 45 µM Incubation Time: 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours Result: Effectively inhibited the proliferation of A549 cells. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 15 µM, 30 µM and 45 µM Incubation Time: 24 hours Result: Induced apoptosis in A549 cells. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 15 µM, 30 µM and 45 µM Incubation Time: 24 hours Result: Arrested cells in the G1 phase. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 15 µM, 30 µM and 45 µM Incubation Time: 24 hours Result: BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner. |
| In Vivo | Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3]. |
| References |
| Molecular Formula | C68H48O44 |
|---|---|
| Molecular Weight | 1569.08000 |
| Exact Mass | 1568.15000 |
| PSA | 732.84000 |
| LogP | 2.17020 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | LZ7000000 |
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Characterization of the effect of Epilobium extracts on human cell proliferation.
Pharmacology 69(2) , 79-87, (2003) We have previously shown that extracts of different Epilobium species, a phytotherapeutic agent used in folk medicine as a treatment for benign prostatic hyperplasia, inhibit proliferation of human pr... |
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A macrocircular ellagitannin, oenothein B, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase.
Biochem. Biophys. Res. Commun. 210(2) , 329-37, (1995) Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tum... |
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The involvement of ATP produced via (ADP-Ribose)n in the maintenance of DNA replication apparatus during DNA repair.
Biol. Pharm. Bull. 30(3) , 447-50, (2007) The formation of ATP produced from poly(ADP-ribose) [(ADP-R)n] has been suggested to be required to repair damaged DNA. Here we investigate whether this ATP is involved in DNA replication processes du... |