ASC-JM-17
ASC-JM-17 structure
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Common Name | ASC-JM-17 | ||
|---|---|---|---|---|
| CAS Number | 1039760-91-2 | Molecular Weight | 464.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H32O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ASC-JM-17ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies. |
| Name | ASC-JM-17 |
|---|
| Description | ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies. |
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| Molecular Formula | C28H32O6 |
|---|---|
| Molecular Weight | 464.56 |