Tepoxalin

Modify Date: 2024-01-02 14:53:20

Tepoxalin structure	Common Name	Tepoxalin
	CAS Number	103475-41-8	Molecular Weight	385.844
	Density	1.3±0.1 g/cm3	Boiling Point	573.0±60.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀ClN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	300.3±32.9 °C

Use of Tepoxalin

Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile[1].

Name	tepoxalin
Synonym	More Synonyms

Description	Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Argentieri DC, et al. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther. 1994 Dec;271(3):1399-408.

Density	1.3±0.1 g/cm3
Boiling Point	573.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀ClN₃O₃
Molecular Weight	385.844
Flash Point	300.3±32.9 °C
Exact Mass	385.119324
PSA	67.59000
LogP	3.84
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.610

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8002500

CHEMICAL NAME :: 1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-me thyl-

CAS REGISTRY NUMBER :: 103475-41-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H20-Cl-N3-O3

MOLECULAR WEIGHT :: 385.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1085 mg/kg/31D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7280 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 54600 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

4-Anisylhydrazi...

CAS#:19501-58-7

N/A

CAS#:142791-64-8

~71%

Tepoxalin

CAS#:103475-41-8

N/A

CAS#:149065-93-0

Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

6-(4-CHLOROPHEN...

CAS#:111881-78-8

Tepoxalin

CAS#:103475-41-8

Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

5-[2-(4-chlorop...

CAS#:142791-63-7

Tepoxalin

CAS#:103475-41-8

Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

N/A

CAS#:144192-64-3

Tepoxalin

CAS#:103475-41-8

Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

4-Anisylhydrazi...

CAS#:19501-58-7

Tepoxalin

CAS#:103475-41-8

Literature: Synthesis, , # 1 p. 18 - 20

3-[5-(4-chlorop...

CAS#:114150-42-4

Tepoxalin

CAS#:103475-41-8

Literature: Synthesis, , # 1 p. 18 - 20

methylhydroxyla...

CAS#:4229-44-1

N/A

CAS#:114151-49-4

Tepoxalin

CAS#:103475-41-8

Literature: Synthesis, , # 1 p. 18 - 20

O-(N-methylamin...

CAS#:144192-63-2

Tepoxalin

CAS#:103475-41-8

Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

Precursor 6
CAS#:19501-58-7 4-Anisylhydrazi... CAS#:111881-78-8 6-(4-CHLOROPHEN... CAS#:142791-63-7 5-[2-(4-chlorop... CAS#:144192-63-2 O-(N-methylamin...
CAS#:114150-42-4 3-[5-(4-chlorop... CAS#:4229-44-1 methylhydroxyla...
DownStream 0

Zubrin

Tepoxalinum [Latin]

3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide

1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-

5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide

Tepoxalin

Tepoxalin [USAN:INN]

Tepoxaline

Tepoxalina [Spanish]

Tepoxalina

3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide

3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide

Tepoxaline [French]

DC Chemicals Limited
China
Product Name: Tepoxalin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Tepoxalin

Use of Tepoxalin

Names

Tepoxalin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms