Maraviroc-d6

Modify Date: 2024-01-16 17:21:00

Maraviroc-d6 structure	Common Name	Maraviroc-d6
	CAS Number	1033699-22-7	Molecular Weight	519.70300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₃₅D₆F₂N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Maraviroc-d6

Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV[1][2].

Name	4,4-difluoro-N-((S)-3-((1R,3R,5S)-3-(3-methyl-5-(propan-2-yl-1,1,1,3,3,3-d6)-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide

Description	Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472 [3]. Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802. [4]. Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64. [5]. Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.

Molecular Formula	C₂₉H₃₅D₆F₂N₅O
Molecular Weight	519.70300
Exact Mass	519.36600
PSA	63.05000
LogP	6.27970