tafetinib
Modify Date: 2025-09-12 22:31:34
tafetinib structure
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Common Name | tafetinib | ||
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| CAS Number | 1032265-57-8 | Molecular Weight | 424.51 | |
| Density | 1.251±0.06 g/cm3(Predicted) | Boiling Point | 618.2±55.0 °C(Predicted) | |
| Molecular Formula | C24H29FN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of tafetinibTafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis[1]. |
| Name | tafetinib |
|---|---|
| Synonym | More Synonyms |
| Description | Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis[1]. |
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| Related Catalog | |
| References |
| Density | 1.251±0.06 g/cm3(Predicted) |
|---|---|
| Boiling Point | 618.2±55.0 °C(Predicted) |
| Molecular Formula | C24H29FN4O2 |
| Molecular Weight | 424.51 |
| InChIKey | KGSRYTUWXUESJK-FXBPSFAMSA-N |
| SMILES | CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCCC2=C1C(=O)Nc2ccc(F)cc21 |
| SIM-010603 |
| SIM010603 |