Trelagliptin succinate
Modify Date: 2025-08-21 19:32:36
Trelagliptin succinate structure
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Common Name | Trelagliptin succinate | ||
|---|---|---|---|---|
| CAS Number | 1029877-94-8 | Molecular Weight | 475.470 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H26FN5O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Trelagliptin succinateTrelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance. |
| Name | 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile,butanedioic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance. |
|---|---|
| Related Catalog | |
| References |
[1]. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus [2]. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus |
| Molecular Formula | C22H26FN5O6 |
|---|---|
| Molecular Weight | 475.470 |
| Exact Mass | 475.186707 |
| PSA | 171.65000 |
| LogP | 1.23468 |
| InChIKey | OGCNTTUPLQTBJI-XFULWGLBSA-N |
| SMILES | Cn1c(=O)cc(N2CCCC(N)C2)n(Cc2cc(F)ccc2C#N)c1=O.O=C(O)CCC(=O)O |
| Storage condition | -20℃ |
| Hazard Codes | Xi |
|---|
| Trelagliptin (succinate) |
| Trelagliptin succinate [USAN] |
| Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-, butanedioate (1:1) |
| SYR472 succinate |
| Zafatek |
| SYR 472 |
| 2-({[6-[(3R)-3-aminopipidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)- yl}methyl)-4-fluorobenzonitrile hydrogen butanedioate |
| Succinic acid - 2-({6-[(3R)-3-amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)-4-fluorobenzonitrile (1:1) |
| SYR111472 Succinate |
| SYR-472 |
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- Shanghai Nianxing Industrial Co., Ltd
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- China
- Product Name: 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile,butanedioic acid
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
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