ALA-ALA-PHE-CHLOROMETHYLKETONE TFA

Modify Date: 2024-02-28 12:13:43

ALA-ALA-PHE-CHLOROMETHYLKETONE TFA structure	Common Name	ALA-ALA-PHE-CHLOROMETHYLKETONE TFA
	CAS Number	102129-66-8	Molecular Weight	339.81700
	Density	1.215g/cm3	Boiling Point	508.9ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₂ClN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	261.6ºC

Use of ALA-ALA-PHE-CHLOROMETHYLKETONE TFA

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research[1].

Name	(2S)-2-amino-N-[(2S)-2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]propanoyl]propanamide
Synonym	More Synonyms

Description	AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	AAF-CMK (0-20 μM; 24 h) shows potentiated antitumor effects of U937 leukemia cells in combination with TRAIL or TNF[1]. AAF-CMK (20 μM; 24 h) increases TNF- and TRAIL-induced U937 cell apoptosis[1]. Cell Viability Assay[1] Cell Line: U937 human promonocytic leukemia cells Concentration: 0-20 μM Incubation Time: 24 h Result: Resulted in the potentiation of growth inhibitory cytostatic effects of TRAIL as well as TNF. Apoptosis Analysis[1] Cell Line: U937 human promonocytic leukemia cells Concentration: 20 μM Incubation Time: 24 h Result: Increased the percentage of apoptotic cells to 55.8% in combination with TRAIL. Increased number of cells with characteristic apoptotic morphology in groups treated with AAF-CMK and both TRAIL or TNF compared to each group treated alone.

AAPCK

Alanyl-alanyl-phenylalanine chloromethyl ketone

Ala-ala-phe-chloromethyl ketone

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