MCI-INI-3
Modify Date: 2025-09-18 12:15:38
MCI-INI-3 structure
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Common Name | MCI-INI-3 | ||
|---|---|---|---|---|
| CAS Number | 1011366-31-6 | Molecular Weight | 373.368 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H15N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MCI-INI-3MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells. |
| Name | MCI-INI-3 |
|---|
| Description | MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells. |
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| References | 1. Jianfeng Li, et al. Commun Biol. 2021 Dec 21;4(1):1420. |
| Molecular Formula | C21H15N3O4 |
|---|---|
| Molecular Weight | 373.368 |
| InChIKey | DCSWTUKGGUNNLU-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc(-c2ccc3c(c2)OCO3)nc2cc(-c3ccccc3)nn12 |