CY 208-243

Modify Date: 2025-11-27 13:43:28

CY 208-243 Structure
CY 208-243 structure
Common Name CY 208-243
CAS Number 100999-26-6 Molecular Weight 274.36000
Density 1.225 g/cm3 Boiling Point 466.5ºC at 760 mmHg
Molecular Formula C19H18N2 Melting Point 227-228ºC
MSDS N/A Flash Point 236ºC

 Use of CY 208-243


CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity[1].

 Names

Name CY 208-243,(-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Synonym More Synonyms

 CY 208-243 Biological Activity

Description CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity[1].
Related Catalog
Target

dopamine D1 receptor[1]

In Vivo Pretreatment with CY 208-243 (2.5 mg/kg; s.c.) prevents the increase of DA release and metabolism induced by the D-1 antagonist, SCH 23390 (0.05 mg/kg; s.c.)[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 2.5 mg/kg Administration: Subcutaneous Result: Prevented the increase of DA release and metabolism induced by the D-1 antagonist.
References

[1]. Imperato A, et al. CY 208-243, a novel dopamine D-1 receptor agonist, fails to modify dopamine release in freely moving rats. Eur J Pharmacol. 1989 Jan 24;160(1):155-8.

[2]. Temlett JA, et al. The D-1 dopamine receptor partial agonist, CY 208-243, exhibits antiparkinsonian activity in the MPTP-treated marmoset. Eur J Pharmacol. 1988 Nov 1;156(2):197-206.

 Chemical & Physical Properties

Density 1.225 g/cm3
Boiling Point 466.5ºC at 760 mmHg
Melting Point 227-228ºC
Molecular Formula C19H18N2
Molecular Weight 274.36000
Flash Point 236ºC
Exact Mass 274.14700
PSA 19.03000
LogP 3.60780
Vapour Pressure 7.02E-09mmHg at 25°C
Index of Refraction 1.697

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

SynaptoRedTM C2
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