PR5-LL-CM01
Modify Date: 2025-08-25 19:40:13
PR5-LL-CM01 structure
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Common Name | PR5-LL-CM01 | ||
|---|---|---|---|---|
| CAS Number | 1005307-86-7 | Molecular Weight | 401.518 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H27N7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PR5-LL-CM01PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM; displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8; exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666; significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo. |
| Name | PR5-LL-CM01 |
|---|
| Description | PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM; displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8; exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666; significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo. |
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| References | References 1. Prabhu L, et al. Oncotarget. 2017 Jun 20;8(25):39963-39977. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C23H27N7 |
|---|---|
| Molecular Weight | 401.518 |