MMBO
Modify Date: 2025-08-25 22:17:53
MMBO structure
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Common Name | MMBO | ||
|---|---|---|---|---|
| CAS Number | 1005203-15-5 | Molecular Weight | 338.380 | |
| Density | 1.4±0.0 g/cm3 | Boiling Point | 579.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C18H14N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 304.0±0.0 °C | |
Use of MMBOMMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models. |
| Name | 2-Methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole |
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| Synonym | More Synonyms |
| Description | MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models. |
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| References | References 1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40. View Related Products by Target GSK-3 |
| Density | 1.4±0.0 g/cm3 |
|---|---|
| Boiling Point | 579.0±0.0 °C at 760 mmHg |
| Molecular Formula | C18H14N2O3S |
| Molecular Weight | 338.380 |
| Flash Point | 304.0±0.0 °C |
| Exact Mass | 338.073000 |
| LogP | 2.27 |
| Vapour Pressure | 0.0±0.0 mmHg at 25°C |
| Index of Refraction | 1.713 |
| InChIKey | RCKYSTKYIVULEK-DEOSSOPVSA-N |
| SMILES | Cc1nnc(-c2ccc3occ(-c4ccc(S(C)=O)cc4)c3c2)o1 |
| 1,3,4-Oxadiazole, 2-methyl-5-[3-[4-[(S)-(1S)-methylsulfinyl]phenyl]-5-benzofuranyl]- |
| 2-Methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole |