GS-9256

Modify Date: 2024-01-28 17:35:22

GS-9256 Structure
GS-9256 structure
Common Name GS-9256
CAS Number 1001094-46-7 Molecular Weight 957.46100
Density N/A Boiling Point N/A
Molecular Formula C46H56ClF2N6O8PS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GS-9256


GS-9256 is a selective HCV NS3 protease inhibitor. GS-9256 has good pharmacokinetic properties and antiviral activity[1].

 Names

Name gs-9256
Synonym More Synonyms

 GS-9256 Biological Activity

Description GS-9256 is a selective HCV NS3 protease inhibitor. GS-9256 has good pharmacokinetic properties and antiviral activity[1].
Related Catalog
In Vitro GS-9256 (0.002-0.183 μM) has a mean EC50 value of 20 nM in GT1b huh-luc cells with a replicon encoding luciferase[1]. GS-9256 (3 μM) retains wild-type activity against all NS5B and NS5A inhibitor-resistant mutations tested and is metabolically stable in microsomes and hepatocytes including rodents, dogs and humans[1].
In Vivo GS-9256 (1 mg/kg, i.v., 30 min) is highly bioavailable in mice (near 100%) and moderately bioavailable in rats (14%), dogs (21%) and monkeys (14%). The elimination half-life is approximately 2 hours in mice, 0.6 hours in rats, 5 hours in dogs, and 4 hours in monkeys[1]. The pharmacokinetic parameters of GS-9256(IV, 2 mg/kg mouse and 1 mg/kg rat, dog, monkey; Oral, 50 mg/kg mouse, 5 mg/kg rat and monkey, 4 mg/kg dog) - Parameters CD-1 mouse Sprague Dawley rat Beagle dog Cynomolgus monkey Intravenous CL(L/h/kg) 2.0 1.26 0.04 0.33 Vss (L/kg) 2.3 0.16 0.09 0.27 t1/2(h) 2.35 0.61 4.88 3.95 MRT(h) 1.15 0.13 2.11 0.82 Oral Tmax(h) 3.00 0.67 2.00 2.67 Cmax(nM) 11116 265 4369 604 t1/2(h) 1.31 0.53 4.22 4.42 AUC0-∞(nM*h) 58959 445 21043 2304 F(%) Complete 13.9 21 14

 Chemical & Physical Properties

Molecular Formula C46H56ClF2N6O8PS
Molecular Weight 957.46100
Exact Mass 956.32700
PSA 219.36000
LogP 10.28240

 Synonyms

gs9256
unii-8v42y78hru