N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide

Modify Date: 2024-09-15 11:42:48

N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide structure	Common Name	N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide
	CAS Number	1000306-34-2	Molecular Weight	419.49500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₅N₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide

KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research[1].

Name	N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide

Description	KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 480 ± 44 nM (Kv1.5), 15100 nM (hERG)[1]
References	[1]. Blass BE, et al. Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem. 2009 Nov 12;52(21):6531-4.

Molecular Formula	C₂₀H₂₅N₃O₅S
Molecular Weight	419.49500
Exact Mass	419.15100
PSA	96.56000
LogP	3.53690

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide

Use of N-{(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxo-1- imidazolidinyl}methanesulfonamide

Names

Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.