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258818-34-7 881851-50-9

258818-34-7

258818-34-7 structure
258818-34-7 structure
  • Name: Larazotide
  • Chemical Name: 2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
  • CAS Number: 258818-34-7
  • Molecular Formula: C32H55N9O10
  • Molecular Weight: 725.83300
  • Catalog: Signaling Pathways Cytoskeleton Gap Junction Protein
  • Create Date: 2018-08-25 20:53:18
  • Modify Date: 2024-01-05 10:19:40
  • Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2].
Name 2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
Synonyms UNII-ZN3R5560ZV
AT-2347
Larazotide
Description Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2].
Related Catalog
In Vitro Larazotide (1-100 μM; 5 d) affects Vero cell growth[1]. Larazotide (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively[1]. Larazotide (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells[2]. Larazotide (100 μM; 3 h) inhibits gliadin translocation across Caco-2 monolayers[2]. Larazotide (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells[2]. Cell Cytotoxicity Assay[1] Cell Line: Vero cell line Concentration: 1-100 μM Incubation Time: 5 days Result: Inhibited Vero cell growth with an CC50 value of 82.5 μM.
In Vivo Larazotide (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice[1]. Animal Model: HLA-HCD4/DQ8 double transgenic mice[2] Dosage: 250 μg Administration: Intraperitoneal injection; 250 μg twice a week for 7 weeks Result: Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels.
Density 1.254
Molecular Formula C32H55N9O10
Molecular Weight 725.83300
Exact Mass 725.40700
PSA 301.32000
LogP 0.49980

Chemsrc provides CAS#:258818-34-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 258818-34-7 | Chemsrc address: https://www.chemsrc.com/en/baike/981821.html

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