216167-92-9
216167-92-9 structure
- Name: Camobucol
- Chemical Name: 2-[2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenoxy]acetic acid
- CAS Number: 216167-92-9
- Molecular Formula: C33H50O4S2
- Molecular Weight: 574.87800
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-11-05 13:54:21
- Modify Date: 2025-08-26 18:08:15
-
Camobucol is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.
| Name | 2-[2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenoxy]acetic acid |
|---|---|
| Synonyms |
Camobucol
UNII-FZ7798X3IR |
| Description | Camobucol is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties. |
|---|---|
| Related Catalog | |
| In Vitro | Camobucol exhibits potent antioxidant activity toward lipid peroxides in vitro and displays enhanced cellular uptake. Camobucol selectively inhibits tumor necrosis factor (TNF)-α-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. In addition, Camobucol inhibits cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-α, IL-1β, and IL-6 from human peripheral blood mononuclear cells. Camobucol does not inhibit TNF-α-induced nuclear translocation of nuclear factor of the κ-enhancer in B cells (NF-κB), suggesting that the mechanism of action is independent of this redox-sensitive transcription factor[1]. |
| References |
| Molecular Formula | C33H50O4S2 |
|---|---|
| Molecular Weight | 574.87800 |
| Exact Mass | 574.31500 |
| PSA | 117.36000 |
| LogP | 9.66610 |
| Storage condition | 2-8℃ |