913827-99-3

913827-99-3 structure

Name: CS 2100
Chemical Name: 1-({4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thieny l}methyl)-3-azetidinecarboxylic acid
CAS Number: 913827-99-3
Molecular Formula: C₂₅H₂₃N₃O₄S
Molecular Weight: 461.53
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2017-09-24 03:30:21
Modify Date: 2024-02-03 10:55:16
CS-2100 (Compound 10b) is a potent, selective, orally active and S1P3-sparing S1P1 agonist with an EC50 of 4.0 nM for human S1P1. CS-2100 shows in vivo immunosuppressive efficacy in rats with an ID50 (infective dose) of 0.407 mg/kg for HvGR[1].

Name	1-({4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thieny l}methyl)-3-azetidinecarboxylic acid
Synonyms	1-({4-[1-(3-oxo-3-phenyl-propyl)-1H-benzoimidazol-2-ylmethyl]-piperazin-1-yl}-acetyl)-pyrrolidine 1-({4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid Pyrrolidine,1-((4-((1-(3-oxo-3-phenylpropyl)-1H-benzimidazol-2-yl)methyl)-1-piperazinyl)acetyl) 1-(2'-Benzoyleth-1'-yl)-2-(4''-pyrrolidinocarbonylmethylpiperazine-1''-ylmethyl)benzimidazole

Description	CS-2100 (Compound 10b) is a potent, selective, orally active and S1P3-sparing S1P1 agonist with an EC50 of 4.0 nM for human S1P1. CS-2100 shows in vivo immunosuppressive efficacy in rats with an ID50 (infective dose) of 0.407 mg/kg for HvGR[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
Target	EC50: 4.0 nM (human S1P1)[1]
References	[1]. Nakamura T, et al. Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92.