1030377-33-3
1030377-33-3 structure
- Name: Suvorexant(MK-4305)
- Chemical Name: suvorexant
- CAS Number: 1030377-33-3
- Molecular Formula: C23H23ClN6O2
- Molecular Weight: 450.921
- Catalog: Biochemical Inhibitor G protein coupled receptor(GPCR & G Protein) OX Receptor Antagonist
- Create Date: 2018-04-10 08:00:00
- Modify Date: 2024-01-03 15:03:19
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Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
| Name | suvorexant |
|---|---|
| Synonyms |
Belsomra
[(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone [(R)-4-(5-chlorobenzoxazol-2-yl)-7-methyl-[1,4]diazepan-1-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)methanone Methanone, [(7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]- [(R)-4-(5-chlorobenzooxazol-2-yl)-7-methyl-[1,4]diazepan-1-yl](5-methyl-2-[1,2,3]triazol-2-yl-phenyl)methanone Suvorexant 5-chloro-2-{(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}-1,3-benzoxazole DORA-analogue [(7R)-4-(5-chlorobenzoxazol-2-yl)-7-methylhexahydro-1H-1,4-diazepin-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone MK-4305 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 669.8±65.0 °C at 760 mmHg |
| Melting Point | 153℃ |
| Molecular Formula | C23H23ClN6O2 |
| Molecular Weight | 450.921 |
| Flash Point | 358.9±34.3 °C |
| Exact Mass | 450.157104 |
| PSA | 80.29000 |
| LogP | 3.62 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.703 |
| Hazard Codes | Xi |
|---|
| Precursor 7 | |
|---|---|
| DownStream 0 | |
![(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole structure](https://www.chemsrc.com/caspic/317/1266975-27-2.png)
![(R)-4-(5-Chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-ium (2S,3S)-2,3-bis(benzoyloxy)-3-carboxypropanoate structure](https://www.chemsrc.com/caspic/405/1276666-14-8.png)
