285570-60-7

285570-60-7 structure

Name: Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt
Chemical Name: Ac-DEVD-CMK
CAS Number: 285570-60-7
Molecular Formula: C₂₁H₃₁ClN₄O₁₁
Molecular Weight: 550.944
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-05-14 22:07:13
Modify Date: 2025-08-23 10:15:43
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3].

Name	Ac-DEVD-CMK
Synonyms	L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]- N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-valinamide

Description	Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Metabolic Disease
Target	Caspase-3
In Vitro	Ac-DEVD-CMK (100 μM; 24 小时) 抑制 IDB 诱导的细胞凋亡[3]。 Apoptosis Analysis[3] Cell Line: Jurkat cells Concentration: 100 μM Incubation Time: 24 h Result: Inhibited ingenol IDB (10 μM)-induced apoptosis.
In Vivo	Ac-DEVD-CMK (Caspase-3 Inhibitor III; 25 mg/kg; 腹腔给药; 单剂量; APAP 后 3 小时) 显着减弱对乙酰氨基酚 (APAP; HY-66005) 诱导的肝损伤 (AILI)[4]。 Animal Model: 6- to 8-week-old females and males Sdc1-/- mice[4] Dosage: 25 mg/kg Administration: IP; single dose; 3 hours post-APAP Result: Significantly attenuated APAP (ip; 500 or 625 mg/kg)-induced liver injury (AILI), indicating that inhibition of GSK-3β or caspase-3 activity mitigates liver damage.
References	[1]. Lu Cai, et al. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes. 2002 Jun;51(6):1938-48. [2]. M M Mocanu, et al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May;130(2):197-200. [3]. M Blanco-Molina, et al. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway. Chem Biol. 2001 Aug;8(8):767-78. [4]. Eon Jeong Nam, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66(5):1601-1615.

Density	1.4±0.1 g/cm3
Boiling Point	1048.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₁ClN₄O₁₁
Molecular Weight	550.944
Flash Point	587.7±34.3 °C
Exact Mass	550.167786
PSA	245.37000
LogP	0.41
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.539

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