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China
Product Name: Hymeglusin
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29066-42-0

29066-42-0 structure

29066-42-0 structure

Name: hymeglusin
Chemical Name: Hymeglusin
CAS Number: 29066-42-0
Molecular Formula: C₁₈H₂₈O₅
Molecular Weight: 324.412
Catalog: Research Areas Cancer
Create Date: 2017-12-11 00:29:16
Modify Date: 2024-01-09 10:05:31
Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].

Name	Hymeglusin
Synonyms	(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid 2,4-Undecadienoic acid, 11-[(2R,3R)-3-(hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-, (2E,4E,7R)- hymeglusin

Description	Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Metabolic Disease
Target	IC50: 1.2 μM (HMG-CoA)[2][3]
In Vitro	Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC50/IC50) of Hymeglusin is 11. The EC50 of Hymeglusin in K562 cells is 4.5 μM[1].
In Vivo	At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %[2].
References	[1]. Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19. [2]. Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92. [3]. Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.

Density	1.1±0.1 g/cm3
Boiling Point	516.6±15.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₈O₅
Molecular Weight	324.412
Flash Point	181.3±13.9 °C
Exact Mass	324.193665
PSA	83.83000
LogP	2.59
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.510

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ1170000

CHEMICAL NAME :: 2,4-Undecadienoic acid, 11-(3-(hydroxymethyl)-4-oxo-2-oxetanyl)-3,5,7-trimeth yl-, (2R-(2-alpha(2E,4E,7R*),3-beta))-

CAS REGISTRY NUMBER :: 29066-42-0

LAST UPDATED :: 199406

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H28-O5

MOLECULAR WEIGHT :: 324.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 41,247,1988

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 41,247,1988

RIDADR	NONH for all modes of transport
RTECS	YQ1170000

Precursor 2
247166-82-1 2385-77-5
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