Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Urea,N-(2-chloroethyl)-N'-(2-hydroxyethyl)-N-nitroso-
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Purity: 98.0%
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60784-46-5

60784-46-5 structure

60784-46-5 structure

Name: elmustine
Chemical Name: 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
CAS Number: 60784-46-5
Molecular Formula: C₅H₁₀ClN₃O₃
Molecular Weight: 195.60400
Catalog: API Antineoplastic agents Alkylating agent
Create Date: 2018-09-28 12:06:27
Modify Date: 2024-01-01 18:21:49

Name	1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
Synonyms	Hydroxyethyl CNU CNU-ethanol 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitroso urea N-(2-Hydroxyethyl)-N'-(2-chloroethyl)-N'-nitrosourea N1-(2-hydroxyethyl)-N3-(2-chloroethyl)-N3-nitrosourea Hecnu Elmustine Elmustine [INN] Elmustinum [Latin] Elmustina [Spanish]

Density	1.45g/cm3
Melting Point	56°C
Molecular Formula	C₅H₁₀ClN₃O₃
Molecular Weight	195.60400
Exact Mass	195.04100
PSA	82.00000
LogP	0.30140
Index of Refraction	1.549

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS4986000

CHEMICAL NAME :: Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-

CAS REGISTRY NUMBER :: 60784-46-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C5-H10-Cl-N3-O3

MOLECULAR WEIGHT :: 195.63

WISWESSER LINE NOTATION :: Q2MVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25300 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - mouse Lung

DOSE/DURATION :: 1 mg/L/1H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 44,87,1977

113900-20-2 structure

113900-20-2

141-43-5 structure

141-43-5

~%

60784-46-5 structure

60784-46-5

Literature: Barcelo, Gerard; Senet, Jean-Pierre; Sennyey, Gerard Synthesis, 1987 , # 11 p. 1027 - 1029

Precursor 2
113900-20-2 141-43-5
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