95094-00-1
95094-00-1 structure
- Name: (S)-(-)-Carvedilol
- Chemical Name: (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
- CAS Number: 95094-00-1
- Molecular Formula: C24H26N2O4
- Molecular Weight: 406.47400
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2018-02-10 08:00:00
- Modify Date: 2024-01-03 14:26:16
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(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].
| Name | (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol |
|---|---|
| Synonyms |
UNII-0K47UL67F2 component OGHNVEJMJSYVRP-KRWDZBQOSA-N
(S)-(-)-Carvedilol Carvedilol Impurity 11 |
| Description | (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1]. |
|---|---|
| Related Catalog | |
| Target |
β/α-1 adrenergic receptor[1] |
| In Vitro | The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers[1]. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro[1]. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs[1]. |
| References |
| Density | 1.25 g/cm3 |
|---|---|
| Boiling Point | 655.2ºC at 760 mmHg |
| Melting Point | 114-115ºC |
| Molecular Formula | C24H26N2O4 |
| Molecular Weight | 406.47400 |
| Flash Point | 350.1ºC |
| Exact Mass | 406.18900 |
| PSA | 75.74000 |
| LogP | 4.12890 |
| Storage condition | 2-8°C |
|
~%
95094-00-1 |
| Literature: WO2007/97504 A1, ; Page/Page column 24-27 ; |
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95094-00-1 |
| Literature: Crystal Growth and Design, , vol. 10, # 6 p. 2713 - 2733 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |