21291-40-7
21291-40-7 structure
- Name: Fructosyl-lysine
- Chemical Name: fructosyllysine
- CAS Number: 21291-40-7
- Molecular Formula: C12H24N2O7
- Molecular Weight: 308.32800
- Catalog: Research Areas Metabolic Disease
- Create Date: 2016-11-03 10:44:29
- Modify Date: 2024-01-04 15:51:48
-
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1].
| Name | fructosyllysine |
|---|
| Description | Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: precursor to glucosepane[2] |
| In Vitro | Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2]. Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2]. Fructosyl-lysine (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2]. |
| In Vivo | Fructosyl-lysine and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1]. |
| References |
| Molecular Formula | C12H24N2O7 |
|---|---|
| Molecular Weight | 308.32800 |
| Exact Mass | 308.15800 |
| PSA | 173.34000 |