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107348-47-0

107348-47-0 structure
107348-47-0 structure
  • Name: PPC-NHS ester
  • Chemical Name: 3-[[1-(2,5-dioxopyrrolidin-1-yl)-2H-pyridin-2-yl]disulfanyl]butanoate
  • CAS Number: 107348-47-0
  • Molecular Formula: C13H14N2O4S2
  • Molecular Weight: 327.39900
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2016-06-14 03:04:05
  • Modify Date: 2024-01-10 12:02:15
  • PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name 3-[[1-(2,5-dioxopyrrolidin-1-yl)-2H-pyridin-2-yl]disulfanyl]butanoate
Synonyms MFCD28398150
Description PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Density 1.43g/cm3
Boiling Point 468.8ºC at 760mmHg
Molecular Formula C13H14N2O4S2
Molecular Weight 327.39900
Flash Point 237.3ºC
Exact Mass 327.04700
PSA 131.35000
LogP 0.54770
Vapour Pressure 5.81E-09mmHg at 25°C
Index of Refraction 1.634
Storage condition -20°C