68112-21-0

68112-21-0 structure

Name: Elasnin
Chemical Name: 3,5-dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)pyran-2-one
CAS Number: 68112-21-0
Molecular Formula: C₂₄H₄₀O₄
Molecular Weight: 392.57
Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
Create Date: 2018-06-11 19:04:10
Modify Date: 2025-08-25 13:47:16
Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain[1].

Name	3,5-dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)pyran-2-one
Synonyms	Elasnin

Description	Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
References	[1]. S Omura, et al. Elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. Biochem Biophys Res Commun. 1978 Jul 28;83(2):704-9.

Density	1.001g/cm3
Boiling Point	521ºC at 760 mmHg
Molecular Formula	C₂₄H₄₀O₄
Molecular Weight	392.57
Flash Point	166.6ºC
Exact Mass	392.29300
PSA	67.51000
LogP	6.45380
Index of Refraction	1.491

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0509600

CHEMICAL NAME :: 2H-Pyran-2-one, 3,5-dibutyl-6-(1-butyl-2-oxoheptyl)-4-hydroxy-

CAS REGISTRY NUMBER :: 68112-21-0

BEILSTEIN REFERENCE NO. :: 1265379

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H40-O4

MOLECULAR WEIGHT :: 392.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1116,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1116,1978

73907-88-7

~66%

68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

73891-54-0

~92%

68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

74583-81-6

68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

74583-82-7

68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

60988-34-3

68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

74583-78-1

68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

65837-08-3

68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

99903-27-2

68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

74583-83-8

68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

Precursor 6
73891-54-0 74583-81-6 74583-82-7 60988-34-3
74583-78-1 65837-08-3
DownStream 0

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