2393-59-1

2393-59-1 structure

Name: β-Muricholic Acid
Chemical Name: (3α,5β,6β,7β)-3,6,7-Trihydroxycholan-24-oic acid
CAS Number: 2393-59-1
Molecular Formula: C₂₄H₄₀O₅
Molecular Weight: 408.57100
Catalog: Research Areas Metabolic Disease
Create Date: 2017-06-05 13:10:33
Modify Date: 2024-01-18 17:08:04
β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD)[1][2].

Name	(3α,5β,6β,7β)-3,6,7-Trihydroxycholan-24-oic acid
Synonyms	2-Cyan-3-(3-methylphenyl)-2-butensaeure-ethylester

Description	β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD)[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	β-Muricholic acid (100µM; 48 h) 抑制小鼠原代肝细胞中的脂质积累[1]。
In Vivo	β-Muricholic acid (用 0.5% β-鼠胆酸喂食 8 周) 可预防小鼠的饮食诱导或实验性胆固醇胆结石[2]。 Animal Model: 6-8 weeks, Male C57L/J mice (with a lithogenic diet (2% cholesterol and 0.5% cholic acid))[2] Dosage: 0.5% β-muricholic acid Administration: Fed chow with 0.5% β-muricholic acid for 8 weeks Result: Decreased gallstone prevalence to 20% through significantly reducing biliary secretion rate, saturation index, and intestinal absorption of cholesterol, as well as inducing phase boundary shift and an enlarged Region E that prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.
References	[1]. Takada S, et al. Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. Lab Invest. 2021 Feb;101(2):193-203. [2]. Wang DQ, et al. Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J Lipid Res. 2002 Nov;43(11):1960-8.