2393-58-0

2393-58-0 structure

Name	(3α,5β,6β,7α)-3,6,7-Trihydroxycholan-24-oic acid
Synonyms	Muricholic acid α-Muricholic acid

Description	α-Muricholic acid is the most abundant primary bile acid in rodents[1][2].
Related Catalog	Research Areas >> Endocrinology Research Areas >> Metabolic Disease
In Vivo	Sulfated and non-sulfated bile acids are determined in the intestines and in the feces of 7-month-old germ-free and conventional male mice. The major bile acids from germ-free mice are cholic acid, α-Muricholic acid and β-Muricholic acid[1]. In the context of primary bile acid, α-Muricholic acid is greatly reduced in high-fat diet (HFD)-soybean protein isolate (SPI) mice compared to the HFD controls[2].
References	[1]. Eyssen HJ, et al. Sulfate bile acids in germ-free and conventional mice. Eur J Biochem. 1976 Jul 15;66(3):507-14. [2]. Watanabe K, et al. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids. PLoS One. 2018 Aug 13;13(8):e0202083.