18842-98-3

18842-98-3 structure

Name: Paederosidic acid
Chemical Name: (1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methyls ulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyr an-4-carboxylic acid
CAS Number: 18842-98-3
Molecular Formula: C₁₈H₂₄O₁₂S
Molecular Weight: 464.441
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-03-21 08:00:00
Modify Date: 2025-08-23 17:11:42
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1].

Name	(1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methyls ulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyr an-4-carboxylic acid
Synonyms	paederosidic acid (1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methylsulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-[[[(methylthio)carbonyl]oxy]methyl]-, (1S,4aS,5S,7aS)-

Description	Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: apoptosis[1]
In Vitro	Paederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of 40.68, 42.58, and 36.48 μg/ml, respectively[1]. Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells[1]. .
References	[1]. Yu P, et al. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis.Chem Biol Interact. 2017 May 1;269:33-40. [2]. Chen YF, et al. Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.CNS Neurosci Ther. 2014 Feb;20(2):188-90.