1227401-27-5
1227401-27-5 structure
- Name: gn25
- Chemical Name: gn25
- CAS Number: 1227401-27-5
- Molecular Formula: C15H14O6S
- Molecular Weight: 322.333
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2017-08-13 09:14:08
- Modify Date: 2025-08-25 20:07:46
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GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1].
| Name | gn25 |
|---|---|
| Synonyms |
Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-
3-[(5,8-Dimethoxy-1,4-dioxo-1,4-dihydro-2-naphthalenyl)sulfanyl]propanoic acid 1H-Indole-3-propanal,5,7-difluoro |
| Description | GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1]. |
|---|---|
| Related Catalog | |
| In Vitro | GN25 (10 and 20 μM; 24 h) inhibits cell viability of K-Ras-mutated MEF cells[1]. GN25 (5 μM; 4 h) activates p53 in a K-Ras-dependent manner[1]. GN25 (1-10 μM; 1-6 h) induces p53 and p21 in a dose- and time- dependent manner in K-Ras-mutated A549 and HCT116 cell lines[1]. GN25 activates wild-type p53 in p53WT/MT cells[1]. GN25 (0.25 μM) recovers the masking effect of p53 on CK1/GSK3b-mediated Snail phosphorylation[1]. Cell Viability Assay[1] Cell Line: HCT116, A459 and MKN45 cell lines Concentration: 10 μM Incubation Time: 24 h Result: Obviously suppressed the cell viability of HCT116 and A459 cell lines. Cell Proliferation Assay[1] Cell Line: K-Ras-transformed and N-Ras/Myc-transformed MEF cells Concentration: 10 μM and 20 μM Incubation Time: 24 h Result: Inhibited the viability of K-Ras-transformed but not N-Ras/Myc-transformed MEF cells. Western Blot Analysis[1] Cell Line: K-Ras-MEF, N-Ras/Myc-MEF and Nontransformed MEF cells Concentration: 5 μM Incubation Time: 4 h Result: Only induced p53 and p21 in K-Ras-MEF cells. Western Blot Analysis[1] Cell Line: K-Ras-mutated A549, HCT116 cell lines and MKN45 Concentration: 1, 5, and 10 μM Incubation Time: 1, 3, and 6 h Result: Induced p53 and p21 in a dose- and time- dependent manner in A549 and HCT116 cells. |
| In Vivo | GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice[1]. Animal Model: Athymic mice with A549 xenografts[1] Dosage: 10 and 20 mg/kg Administration: Intraperitoneal injection; once a week for 10 weeks Result: Obviously regressed tumors in mice. Showed no significant toxicity in liver, pancreas and kidney. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 608.4±55.0 °C at 760 mmHg |
| Molecular Formula | C15H14O6S |
| Molecular Weight | 322.333 |
| Flash Point | 321.7±31.5 °C |
| Exact Mass | 322.051117 |
| PSA | 115.20000 |
| LogP | 2.19 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.622 |