Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

63989-75-3

63989-75-3 structure

Name: Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Chemical Name: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzamide
CAS Number: 63989-75-3
Molecular Formula: C₂₇H₂₇NO₆
Molecular Weight: 461.50600
Create Date: 2016-01-10 07:39:09
Modify Date: 2025-09-04 09:15:14

Name	N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzamide
Synonyms	N-Benzoyltrimethylcolchicinsaeuremethylaether N-Benzoyl-deacetylcolchicine Colchicine,N-benzoyl-N-deacetyl N-Benzoyl trimethyl colchicinic acid methyl ether N-Benzoyl tmca methyl ether COLCHICINE,N-DEACETYL-N-BENZOYL N-benzoyl-N-deacetylcolchicine

Density	1.28g/cm3
Boiling Point	780.3ºC at 760 mmHg
Molecular Formula	C₂₇H₂₇NO₆
Molecular Weight	461.50600
Flash Point	425.7ºC
Exact Mass	461.18400
PSA	83.09000
LogP	4.55640
Index of Refraction	1.62

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0790000

CHEMICAL NAME :: Colchicine, N-deacetyl-N-benzoyl-

CAS REGISTRY NUMBER :: 63989-75-3

BEILSTEIN REFERENCE NO. :: 3184511

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C27-H27-N-O6

MOLECULAR WEIGHT :: 461.55

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMVR& NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27924 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 12500 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Gastrointestinal - other changes

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

REFERENCE :: CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

3476-50-4

93-97-0

63989-75-3

Literature: Brossi; Sharma; Atwell; Jacobson; Iorio; Molinari; Chignell Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1365 - 1369

186581-53-3

14686-58-9

63989-75-3

Literature: Santavy Chemicke Listy, 1952 , vol. 46, p. 280,284 Chem.Abstr., 1953 , p. 4325

Precursor 3
3476-50-4 93-97-0 186581-53-3
DownStream 0

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