346451-15-8

346451-15-8 structure

Name: Cetirizine Impurity D
Chemical Name: 1,4-bis[(4-chlorophenyl)-phenylmethyl]piperazine,dihydrochloride
CAS Number: 346451-15-8
Molecular Formula: C₃₀H₃₀Cl₄N₂
Molecular Weight: 560.38500
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-12-31 17:17:42
Modify Date: 2025-08-25 16:25:22
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

Name	1,4-bis[(4-chlorophenyl)-phenylmethyl]piperazine,dihydrochloride
Synonyms	MFCD03844641

Description	Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993. [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.