311343-11-0

311343-11-0 structure

Name: I-152
Chemical Name: S-[2-[[(2R)-2-acetamido-3-sulfanylpropanoyl]amino]ethyl] ethanethioate
CAS Number: 311343-11-0
Molecular Formula: C₉H₁₆N₂O₃S₂
Molecular Weight: 264.36
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2017-11-04 09:20:50
Modify Date: 2024-01-14 16:40:59
I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties[1].

Name	S-[2-[[(2R)-2-acetamido-3-sulfanylpropanoyl]amino]ethyl] ethanethioate
Synonyms	Ethanethioic acid,S-(2-(((2R)-2-(acetylamino)-3-mercapto-1-oxopropyl)amino)ethyl)ester s-{2-[(n-acetyl-l-cysteinyl)amino]ethyl} ethanethioate I 152

Description	I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Metabolic Disease
In Vitro	I-152 (1 mM；1 h 或 2 h) 降低了 RAW 264.7 细胞中 NRF2 mRNA 的水平[1]。 I-152 (1 mM；0-60 min) 降低了 RAW 264.7 细胞中 NRF2 和 p53 的水平，增加了 ATF4 的表达[1]。 I-152 (0.062、0.125、0.25 或 1 mM) 增加了 RAW 264.7 细胞中 Gclc mRNA (6 h 或 24 h)、Chac1 mRNA (6 h 或 24 h) 和 Chop mRNA (6 h) 的水平[1]。 I-152 (0.062、0.125、0.25 或 1 mM；2 h) 增加了 RAW 264.7 细胞中 GSH 的水平[1]。 I-152 (1 mM；1、2、6 和 24 h) 激活 RAW 264.7 细胞中 ATF4 mRNA 表达[1]。 I-152 (1 mM；24 h 和 48 h) 对 RAW 264.7 细胞显示出细胞杀伤和生长抑制作用[1]。 Western Blot Analysis[1] Cell Line: RAW 264.7 cells. Concentration: 0.062, 0.125, 0.25, 1, 5 or 10 mM. Incubation Time: 2 h or 24 h. Result: Reduced the expression of NRF2/β-ACTIN, increased the expression of GCLM.
References	[1]. Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175.