105955-01-9
105955-01-9 structure
- Name: KS370G
- Chemical Name: 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
- CAS Number: 105955-01-9
- Molecular Formula: C17H17NO3
- Molecular Weight: 283.32
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2017-12-07 02:18:49
- Modify Date: 2024-03-03 12:06:25
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KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2].
| Name | 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide |
|---|---|
| Synonyms | N-caffeoyl-2-phenylethylamine |
| Description | KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | KS370G (1 mg/kg; oral; once daily for 8 weeks) 通过降低压力过载小鼠心脏 ERK、AKT 和 GSK3β 的磷酸化，改善左心室功能，抑制心脏肥厚[1]。 KS370G (10 mg/kg; oral; once daily for 13 days) 通过减少小鼠炎症和氧化应激减轻单侧输尿管梗阻引起的肾纤维化[2]。 Animal Model: Pressure-overload ICR mice model[1] Dosage: 1 mg/kg Administration: Oral gavage, once daily for 8 weeks Result: Inhibited cardiac hypertrophy and improved cardiac function induced by pressure overload. Decreased the plasma levels of atrial natriuretic peptide and lactate dehydrogenase. Significantly reduced pressure overload-induced increase of α-SMA and phosphorylation of ERK, AKT and GSK3β. Reduced cardiac collagen accumulation. Animal Model: Male ICR mice, unilateral ureteral obstruction (UUO) model[2] Dosage: 10 mg/kg Administration: Oral, once daily for 13 days Result: Significantly attenuated collagen deposition in the obstructed kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). Significantly lowered the expression of renalinflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b). Reduced renal malondialdehyde levels and reversed the expression of renal antioxidant enzymes (SOD and catalase) after UUO. Significantly inhibited UUOinduced elevated plasma AngII and TGF-β1 levels, TGF-β1 protein expression and Smad3 phosphorylation. |
| References |
| Molecular Formula | C17H17NO3 |
|---|---|
| Molecular Weight | 283.32 |
| Exact Mass | 283.12100 |
| PSA | 73.05000 |
| LogP | 3.31020 |
| RIDADR | NONH for all modes of transport |
|---|