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4055-39-4

4055-39-4 structure
4055-39-4 structure
  • Name: Mitomycin A
  • Chemical Name: mitomycin A
  • CAS Number: 4055-39-4
  • Molecular Formula: C16H19N3O6
  • Molecular Weight: 349.34
  • Catalog: Research Areas Cancer
  • Create Date: 2018-05-16 08:00:00
  • Modify Date: 2025-08-20 17:21:24
  • Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer[1].
Name mitomycin A
Synonyms [(1aS,8S,8aR,8bS)-6,8a-Dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,3,4]pyrrolo[1,2-a]indol-8-yl]methyl Carbamate
mitomycin-A
Mitomycin A
(1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Description Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer[1].
Related Catalog
References

[1]. van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986 Aug;172(1-2):120-7.  

Density 1.5g/cm3
Boiling Point 587.4ºC at 760 mmHg
Melting Point 159-161ºC (dec)
Molecular Formula C16H19N3O6
Molecular Weight 349.34
Flash Point 309.1ºC
Exact Mass 349.12700
PSA 130.10000
LogP 0.00350
Vapour Pressure 8.83E-14mmHg at 25°C
Index of Refraction 1.638

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN1050000
CAS REGISTRY NUMBER :
4055-39-4
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H19-N3-O6
MOLECULAR WEIGHT :
349.38
WISWESSER LINE NOTATION :
T D3 B556 BN EM JV MVTTT&J GO1 H1OVZ KO1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
3 ug/L
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,767,1977
132732-87-7 structure

132732-87-7

~0%

4055-39-4 structure

4055-39-4

110934-24-2 structure

110934-24-2

Literature: Kasai; Kono; Ikeda; Yoda; Hirayama Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7296 - 7299
50-07-7 structure

50-07-7

~81%

4055-39-4 structure

4055-39-4

Literature: Kanda; Kasai Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2515 - 2518
186581-53-3 structure

186581-53-3

7041-61-4 structure

7041-61-4

~51%

4055-39-4 structure

4055-39-4

Literature: Sami, Salah M.; Iyengar, Bhashyam S.; Remers, William A.; Bradner, William T. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 168 - 173
67-56-1 structure

67-56-1

122644-74-0 structure

122644-74-0

~66%

4055-39-4 structure

4055-39-4

Literature: Arai, Hitoshi; Kasai, Masaji Journal of Organic Chemistry, 1993 , vol. 58, # 15 p. 4151 - 4152
7041-61-4 structure

7041-61-4

20667-76-9 structure

20667-76-9

~48%

4055-39-4 structure

4055-39-4

Literature: Vyas; Benigni; Partyka; Doyle Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4307 - 4309
20667-76-9 structure

20667-76-9

50-07-7 structure

50-07-7

~%

4055-39-4 structure

4055-39-4

Literature: Subramaniam; Kohn Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 10519 - 10526
132732-87-7 structure

132732-87-7

~%

4055-39-4 structure

4055-39-4

Literature: Kasai; Kono; Ikeda; Yoda; Hirayama Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7296 - 7299
124-41-4 structure

124-41-4

128583-70-0 structure

128583-70-0

~58%

4055-39-4 structure

4055-39-4

Literature: Furuhata; Komiyama; Takeda; Takayanagi; Torii; Mishima; Ogura; Hata Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2651 - 2654
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