85604-00-8
85604-00-8 structure
- Name: Zaltidine
- Chemical Name: 2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine
- CAS Number: 85604-00-8
- Molecular Formula: C8H10N6S
- Molecular Weight: 222.27000
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2018-07-31 09:54:24
- Modify Date: 2025-08-25 16:31:01
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Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action.IC50 Value: Target: H2 receptorin vitro:in vivo: In eight healthy male volunteers single oral doses of 5 mg, 25 mg and 100 mg produced dose-related inhibition of basal and pentagastrin-stimulated acid output (M.A.O.) with an estimated ID50 of 40 mg for the latter. In eight subjects with duodenal ulceration single 100 mg and 200 mg doses produced 85% and 97% inhibition of M.A.O. at peak (3 h post-dose) and 20% and 23% inhibition at 24 h, respectively; inhibition of basal acid output was 97% at 3 h and 50% at 24 h with both doses [1]. One hundred and thirty-five patients were randomly allocated to 4 weeks' treatment with either 150 mg zaltidine once daily or placebo. Fifty-nine were treated for a full 4 weeks with zaltidine before the trial was stopped. Healing rates after 4 weeks of zaltidine and placebo were 86% and 19%, respectively (p less than 0.001) [2].
| Name | 2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine |
|---|---|
| Synonyms |
Zaltidine hydrochloride [USAN]
Zaltidinum Zaltidina Zaltidine Zaltidine HCl Zaltidinum [Latin] Zaltidina [Spanish] ZALTIDINE HYDROCHLORIDE |
| Description | Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action.IC50 Value: Target: H2 receptorin vitro:in vivo: In eight healthy male volunteers single oral doses of 5 mg, 25 mg and 100 mg produced dose-related inhibition of basal and pentagastrin-stimulated acid output (M.A.O.) with an estimated ID50 of 40 mg for the latter. In eight subjects with duodenal ulceration single 100 mg and 200 mg doses produced 85% and 97% inhibition of M.A.O. at peak (3 h post-dose) and 20% and 23% inhibition at 24 h, respectively; inhibition of basal acid output was 97% at 3 h and 50% at 24 h with both doses [1]. One hundred and thirty-five patients were randomly allocated to 4 weeks' treatment with either 150 mg zaltidine once daily or placebo. Fifty-nine were treated for a full 4 weeks with zaltidine before the trial was stopped. Healing rates after 4 weeks of zaltidine and placebo were 86% and 19%, respectively (p less than 0.001) [2]. |
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| Related Catalog | |
| References |
| Density | 1.7g/cm3 |
|---|---|
| Boiling Point | 622.9ºC at 760 mmHg |
| Molecular Formula | C8H10N6S |
| Molecular Weight | 222.27000 |
| Flash Point | 330.5ºC |
| Exact Mass | 222.06900 |
| PSA | 134.21000 |
| LogP | 2.14710 |
| Index of Refraction | 1.844 |
| Storage condition | 2-8℃ |