582316-00-5
582316-00-5 structure
- Name: MX1013
- Chemical Name: 5-fluoro-3-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxopentanoic acid
- CAS Number: 582316-00-5
- Molecular Formula: C18H23FN2O6
- Molecular Weight: 382.38300
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2018-12-23 11:51:12
- Modify Date: 2024-01-10 08:02:07
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MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM[1].
| Name | 5-fluoro-3-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxopentanoic acid |
|---|---|
| Synonyms | Z-Val-DL-Asp-fluoromethylketone |
| Description | MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM[1]. |
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| Related Catalog | |
| Target |
Caspase |
| In Vitro | MX1013 inhibits caspases 1, 3, 6, 7, 8, and 9, with IC50 values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor inhibitor of noncaspase proteases, such as cathepsin B, calpain I, or Factor Xa (IC50 values >10 μm)[1]. MX1013 inhibits three key markers of apoptosis: the proteolytic maturation of caspase 3, the caspase-mediated cleavage of PARP, and the fragmentation of genomic DNA[1]. Cell Proliferation Assay[1] Cell Line: Jurkat T-lymphocytes Concentration: 0, 0.05, 0.1, 0.25, 0.5 μM Incubation Time: Preincubated for 2 h Result: Neither caspase 3 processing nor PARP cleavage could be detected at 0.5 μM. At concentrations of 0.05 μM, caspase 3 processing and PARP cleavage were still markedly reduced. |
| In Vivo | MX1013 is an effective antiapoptotic agent in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects[1]. Animal Model: Female ND4 Swiss Webster mice (16.5-21 g)[1] Dosage: 0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm Tris-HCl, pH 8.0) Administration: Injected i.v. Result: The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg dose protected 100% of the mice at the 3 h time point. |
| References |
| Density | 1.258g/cm3 |
|---|---|
| Boiling Point | 639.809ºC at 760 mmHg |
| Molecular Formula | C18H23FN2O6 |
| Molecular Weight | 382.38300 |
| Flash Point | 340.745ºC |
| Exact Mass | 382.15400 |
| PSA | 121.80000 |
| LogP | 2.21730 |
| Index of Refraction | 1.523 |
| HS Code | 2924299090 |
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| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |