67224-41-3

67224-41-3 structure

Name: ACTH (4-11)
Chemical Name: acth (4-11)
CAS Number: 67224-41-3
Molecular Formula: C₅₀H₇₁N₁₅O₁₁S
Molecular Weight: 1090.26000
Catalog: Peptides
Create Date: 2018-12-23 21:38:57
Modify Date: 2024-01-10 11:57:51
ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

Name	acth (4-11)
Synonyms	Methionyl-glutamyl-histidinyl-phenylalanyl-argininyl-tryptophanyl-glycinyl-lysine MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS H-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-OH MEHFRWGK ADRENOCORTICOTROPIC HORMONE FRAGMENT 4-11 MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS

Description	ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Peptides
In Vitro	α-melanocyte stimulating hormone (MSH) induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. Adrenocorticotropic hormone (ACTH) possesses the same amino acid sequence as MSH does. α-MSH induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. ACTH (4-11) loses almost all activity for the binding to melanocortin receptor 1 (MC1R)[1].
References	[1]. Hirobe T, et al. ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J Exp Zool. 2000 May 1;286(6):632-40.