293736-67-1
293736-67-1 structure
- Name: RTA 744
- Chemical Name: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-phenylmethoxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione,hydrochloride
- CAS Number: 293736-67-1
- Molecular Formula: C34H36ClNO11
- Molecular Weight: 670.10300
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-10-21 01:48:29
- Modify Date: 2025-08-26 14:44:51
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RTA 744 (WP 744) is a Doxorubicin (HY-15142A) analogue. RTA 744 triggers apoptosis and cell killing in NB cells by activating proapoptotic mediators. RTA 744 has proapoptotic and anti-leukemia activities. RTA 744 can be used for cancer research[1][2][3].
| Name | (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-phenylmethoxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione,hydrochloride |
|---|---|
| Synonyms |
Berubicin HCl
WP744 RTA-744 Berubicin hydrochloride (USAN) |
| Description | RTA 744 (WP 744) is a Doxorubicin (HY-15142A) analogue. RTA 744 triggers apoptosis and cell killing in NB cells by activating proapoptotic mediators. RTA 744 has proapoptotic and anti-leukemia activities. RTA 744 can be used for cancer research[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | WP 769 hydrochloride 抑制 K562 细胞的活性，IC50 值为 0.18 mg/mL[1]。 WP 769 hydrochloride (0-100 µM；24 h) 抑制 KBM-5 细胞吸收胸腺嘧啶[2]。 WP 769 hydrochloride (1 µM；15 min) 在 KBM-5 细胞中通过 NF-κB 的 p50 和 p65 亚基激活 NF-κB[2]。 WP 769 hydrochloride (0-100 µM；72 h) 以剂量依赖性方式抑制 Jurkat 和 RIP 缺失的 Jurkat 细胞增值[2]。 Cell Viability Assay[2] Cell Line: KBM-5 cells. Concentration: 0, 0.1, 1, 10 and 100 µM. Incubation Time: 24 h. Result: Inhibited cell viability with dose-dependent manner. Western Blot Analysis[2] Cell Line: KBM-5 cells. Concentration: 0, 0.1, 1 and 10 µM. Incubation Time: 4 h. Result: Increased NF-κB expression with time and dose dependent manner. Cell Viability Assay[3] Cell Line: SH-SY5Y cells. Concentration: 0.1, 1 and 10 µM. Incubation Time: 0, 1, 2, 3, 4 and 5 d. Result: Inhibited cell viability with dose-dependent manner. Apoptosis Analysis[3] Cell Line: SH-SY5Y cells. Concentration: 50, 500 and 2000 nM. Incubation Time: 48 h. Result: Promoted cell apoptosis. Western Blot Analysis[3] Cell Line: SH-SY5Y cells. Concentration: 0, 0.1, 1.0 or 10 µM. Incubation Time: 0, 0.5, 1, 2, 4, 6, 8, 12 or 24 h. Result: Activated Casp 3 and Casp 9. Increased p53 and NF-κB expression. Reduced IκBα expression. |
| References |
| Molecular Formula | C34H36ClNO11 |
|---|---|
| Molecular Weight | 670.10300 |
| Exact Mass | 669.19800 |
| PSA | 195.07000 |
| LogP | 3.72810 |