104494-35-1

104494-35-1 structure

Name: Kazinol F
Chemical Name: 5-[3-(2,4-dihydroxyphenyl)propyl]-3,4-bis(3-methylbut-2-enyl)benzene-1,2-diol
CAS Number: 104494-35-1
Molecular Formula: C₂₅H₃₂O₄
Molecular Weight: 396.51900
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2016-05-11 19:06:23
Modify Date: 2024-01-12 07:39:49
Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19[1].

Name	5-[3-(2,4-dihydroxyphenyl)propyl]-3,4-bis(3-methylbut-2-enyl)benzene-1,2-diol
Synonyms	Kazinol F

Description	Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Research Areas >> Inflammation/Immunology
In Vitro	Kazinol F 与 Mpro 的催化残基（His41 和 Cys145）相互作用，并表现出良好的结合亲和力 (-8.1kcal/mol)[1]。
References	[1]. Ghosh, Rajesh et al. Identification of polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease inhibitors using in silico docking and molecular dynamics simulation approaches. J Biomol Struct Dyn. vol. 39,17 (2021): 6747-6760.