CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DG9125000
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CHEMICAL NAME :
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Benzoic acid, p-(3-dimethyltriazeno)-, ethyl ester
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CAS REGISTRY NUMBER :
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21600-51-1
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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11
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MOLECULAR FORMULA :
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C11-H15-N3-O2
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MOLECULAR WEIGHT :
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221.29
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WISWESSER LINE NOTATION :
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2OVR DNUNN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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450 mg/kg
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TOXIC EFFECTS :
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Blood - leukopenia Blood - thrombocytopenia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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150 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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760 mg/kg/19W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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805 mg/kg/23W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Blood - lymphoma, including Hodgkin's disease
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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760 mg/kg/19W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
MUTATION DATA
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TYPE OF TEST :
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Host-mediated assay
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TEST SYSTEM :
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Rodent - mouse Yeast - Saccharomyces cerevisiae
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DOSE/DURATION :
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8852 mg/kg
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REFERENCE :
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CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 9,365,1974
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