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13410-86-1

13410-86-1 structure

13410-86-1 structure

Name: Aconiazide
Chemical Name: 2-[2-[(E)-(pyridine-4-carbonylhydrazinylidene)methyl]phenoxy]acetic acid
CAS Number: 13410-86-1
Molecular Formula: C₁₅H₁₃N₃O₄
Molecular Weight: 299.28100
Catalog: Research Areas Infection
Create Date: 2018-09-30 01:47:23
Modify Date: 2024-01-07 02:40:06
Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis[1].

Name	2-[2-[(E)-(pyridine-4-carbonylhydrazinylidene)methyl]phenoxy]acetic acid
Synonyms	[2-(isonicotinoylhydrazono-methyl)-phenoxy]-acetic acid Isonicophen Aconiazid Phenoxalid ACONIAZIDE [2-(Isonicotinoylhydrazono-methyl)-phenoxy]-essigsaeure

Description	Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. KENNETH L. DOOLEY, et al. Fourteen-Day , Repeat-Dose Toxicity Evaluation of Aconiazide _- Administered Orally to Male and Female Fischer 344 Rats. JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Vdume 12, Number 4, 1993

Density	1.3g/cm3
Molecular Formula	C₁₅H₁₃N₃O₄
Molecular Weight	299.28100
Exact Mass	299.09100
PSA	100.88000
LogP	1.69980
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5638000

CHEMICAL NAME :: 4-Pyridinecarboxylic acid, ((2-(carboxymethoxy)phenyl)methylene)hydrazide

CAS REGISTRY NUMBER :: 13410-86-1

BEILSTEIN REFERENCE NO. :: 0300804

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H13-N3-O4

MOLECULAR WEIGHT :: 299.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/14D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,329,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36400 mg/kg/26W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,328,1995

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%