25696-60-0

25696-60-0 structure

Name: Tauro-β-muricholic acid
Chemical Name: tauroβ-muricholic acid
CAS Number: 25696-60-0
Molecular Formula: C₂₆H₄₅NO₇S
Molecular Weight: 515.70300
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-06-15 12:21:06
Modify Date: 2024-01-10 08:13:15
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

Name	tauroβ-muricholic acid
Synonyms	Tauro-β-muricholic Acid Tauro-Beta-muricholic Acid

Description	Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Metabolic Disease
Target	40 μM (FXR)[1]
References	[1]. Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012 Aug 10;424(4):758-64. [2]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35.