80971-60-4

80971-60-4 structure

Name: n-Butyl β-D-fructofuranoside
Chemical Name: (2R,3S,4S,5R)-2-butoxy-2,5-bis(hydroxymethyl)oxolane-3,4-diol
CAS Number: 80971-60-4
Molecular Formula: C₁₀H₂₀O₆
Molecular Weight: 236.26200
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-07-12 21:12:52
Modify Date: 2024-01-11 15:06:48
n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research[1].

Name	(2R,3S,4S,5R)-2-butoxy-2,5-bis(hydroxymethyl)oxolane-3,4-diol
Synonyms	Butyl fructofuranoside

Description	n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Bax Bcl-2
In Vitro	n-Butyl-β-D-fructofuranoside (0-23.6 μg/mL; 24-78 hours) has antiproliferation activity and inhibits the viability of Bel-7402 cells[1]. n-Butyl-β-D-fructofuranoside (0-75 μg/mL; 0-72 hours) inhibits BEL-7402 cells by interfering with cell cycle and inducing apoptosis[1]. Cell Viability Assay[1] Cell Line: Bel-7402 cells Concentration: 0.47, 2.95, 5.90, 11.8, 17.7 and 23.6 μg/mL Incubation Time: 24, 48 and 72 hours Result: Inhibited the proliferation of Bel-7402 cells at both time- and dose-dependent manner. Cell Cycle Analysis[1] Cell Line: Bel-7402 cells Concentration: 0, 50 and 75 μg/mL Incubation Time: 24, 48 and 72 hours Result: Induced cell cycle arrest at G0/G1 phase. Western Blot Analysis[1] Cell Line: Bel-7402 cells Concentration: 23.6 μg/mL Incubation Time: 0, 24, 48 and 72 hours Result: Decreased Bcl-2 and increased Bax and p53 levels in a time manner.
References	[1]. Lu P, et, al. Antiproliferative effects of n-butyl-β-D-fructofuranoside from Kangaisan on Bel-7402 cells. Indian J Pharmacol. 2014 Jan-Feb;46(1):69-75. doi: 10.4103/0253-7613.125175.