35927-38-9

35927-38-9 structure

Name: Vicenin -1
Chemical Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3-[(3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one
CAS Number: 35927-38-9
Molecular Formula: C₂₆H₂₈O₁₄
Molecular Weight: 564.49200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2017-12-27 19:08:38
Modify Date: 2024-01-13 19:51:23
Vicenin 1 is a C-glycosylflavone isolated from the aerial parts of Desmodium styracifolium, has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC50=52.50 μM)[1].

Name	5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3-[(3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one
Synonyms	Vicenin -1

Description	Vicenin 1 is a C-glycosylflavone isolated from the aerial parts of Desmodium styracifolium, has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC50=52.50 μM)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 52.50 μM (ACE)[1]
In Vitro	The target-isolated C-glycosylflavone (Vicenin 1) is evaluated for inhibitory activities. Vicenin 1 embodies effective ACE inhibitory activities with an IC50 value of 52.50 μM. The tested compound 3 (Vicenin 1) shows activity via the generation of chelate complexes within the active center of ACE[1].
References	[1]. Zhang YQ, et al. Bioassay-guided preparative separation of angiotensin-converting enzyme inhibitory C-flavone glycosides from Desmodium styracifolium by recycling complexation high-speed counter-current chromatography. J Pharm Biomed Anal. 2015 Jan;102:276-81.