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70678-95-4

70678-95-4 structure
70678-95-4 structure
  • Name: Hydroxy-PEG4-CH2COOH
  • Chemical Name: 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetic acid
  • CAS Number: 70678-95-4
  • Molecular Formula: C10H20O7
  • Molecular Weight: 252.26200
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-03-26 13:27:16
  • Modify Date: 2025-08-26 13:25:35
  • Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Name 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetic acid
Synonyms Carbomethoxytetraethylenglykol
14-hydroxy-3,6,9,12-tetraoxatetradecanoic acid
3,6,9,12-Tetraoxatetradecanoic acid,14-hydroxy
Description Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Molecular Formula C10H20O7
Molecular Weight 252.26200
Exact Mass 252.12100
PSA 94.45000
112-60-7 structure

112-60-7

3926-62-3 structure

3926-62-3

~%

70678-95-4 structure

70678-95-4

Literature: Chen, Bin; Baumeister, Ute; Pelzl, Gerhard; Das, Malay Kumar; Zeng, Xiangbing; Ungar, Goran; Tschierske, Garsten Journal of the American Chemical Society, 2005 , vol. 127, # 47 p. 16578 - 16591
77303-64-1 structure

77303-64-1

~99%

70678-95-4 structure

70678-95-4

Literature: Nakatsuji, Yohji; Kawamura, Norio; Okahara, Mitsuo; Matsushima, Kenji Synthesis, 1981 , # 1 p. 42 - 44
112-60-7 structure

112-60-7

79-11-8 structure

79-11-8

~58%

70678-95-4 structure

70678-95-4

Literature: Yamaguchi, Kazuo; Kuboniwa, Hitoshi; Murakami, Nobuya; Hirao, Akira; Nakahama, Swiichi; Yamazaki, Noburo Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 4 p. 1097 - 1101
154773-34-9 structure

154773-34-9

~%

70678-95-4 structure

70678-95-4

Literature: Bostic, Heidi E.; Smith, Matthew D.; Poloukhtine, Andrei A.; Popik, Vladimir V.; Best, Michael D. Chemical Communications, 2012 , vol. 48, # 10 p. 1431 - 1433
112-60-7 structure

112-60-7

~%

70678-95-4 structure

70678-95-4

Literature: Nakatsuji, Yohji; Kawamura, Norio; Okahara, Mitsuo; Matsushima, Kenji Synthesis, 1981 , # 1 p. 42 - 44
112-60-7 structure

112-60-7

1068-52-6 structure

1068-52-6

~%

70678-95-4 structure

70678-95-4

Literature: Matsushima,K. et al. Tetrahedron Letters, 1979 , # 36 p. 3445 - 3448
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title: CAS No. 70678-95-4 | Chemsrc address: https://www.chemsrc.com/en/baike/704890.html

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